HER2 Support Group Forums - View Single Post - Attempting to increase rate of Herceptin efficacy,decrease rate of Hercptn resistance

RobinP · 01-28-2006, 08:06 AM

Just wanted to add as an after thought. What about those people who are her2 positive and have the truncated form of the receptor, p85. As you know that form of her2 does not have the cleavage for herceptin to fit in. So I wonder if Herceptin works at all in this case? I wonder how ip85 gets activated at all if it can not heterodimerize and what is the prognosis of p85? I think I heard on a SABC live webcast that about 25% of the early stage her2+ have p85 form of the receptor.

01-28-2006, 08:06 AM	#16
RobinP Senior Member Join Date: Nov 2005 Posts: 943	And more thoughts..................... Just wanted to add as an after thought. What about those people who are her2 positive and have the truncated form of the receptor, p85. As you know that form of her2 does not have the cleavage for herceptin to fit in. So I wonder if Herceptin works at all in this case? I wonder how ip85 gets activated at all if it can not heterodimerize and what is the prognosis of p85? I think I heard on a SABC live webcast that about 25% of the early stage her2+ have p85 form of the receptor. __________________ Robin 2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo