HER2 Support Group Forums - View Single Post - To chemo break or not to break?

al from Canada · 01-25-2006, 03:00 PM

Lyn,

I have seen low dose xeloda mentioned in a trial where they went 21 days on, 7 days off. That actually makes more sense to me than high doses as you achieve steady state for a longer period of time. To me, 500 mg BID makes more sense than 1000 / day, esp. in light of the fact than xeloda has a half-life of 45 minutes.
BTW, there has been no survival advantage associated with high doses of xeloda.

Al

01-25-2006, 03:00 PM	#6
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	Lyn, I have seen low dose xeloda mentioned in a trial where they went 21 days on, 7 days off. That actually makes more sense to me than high doses as you achieve steady state for a longer period of time. To me, 500 mg BID makes more sense than 1000 / day, esp. in light of the fact than xeloda has a half-life of 45 minutes. BTW, there has been no survival advantage associated with high doses of xeloda. Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.