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Herceptin "resistance" may not be the best term--it's still working, just needs help!
In the metastatic setting, they have found if tumors recur/progress on Herceptin it is usually best to keep the patient on herceptin and add something to it. So herceptin "resistance" may be a bad term. It still works, it is just the cancer may have found other ways to multiply that need to be blocked as well. It is like a puppy in the house--you may have blocked the front door, but it will eventually explore and found other doors to get out into the yard and chase that squirrel! It doesn't mean you should leave the front door open, only that you need to close more doors.
Hope this helps!
Lani
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