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al from Canada · 01-17-2006, 10:35 PM

We are all aware of the clinical trials with lapatinib but there are a few other small molecule HER inhibitors that are also undergoing clinical trials. The important thing about small molecule drugs is that they cross the blood / brain barrier.
Al

Tarceva (erlotinib)

Erlotinib and Gemcitabine in Treating Patients With Metastatic Breast Cancer Previously Treated With An Anthracycline and/or a Taxane, North Central Cancer Treatment Group
Erlotinib and Bevacizumab (avastin) in Treating Women With Stage IV Breast Cancer. Memorial Sloan-Kettering Cancer Center
Trastuzumab and Erlotinib as First-Line Therapy in Treating Women With Metastatic Breast Cancer Associated With HER2/neu Overexpression. Jonsson Comprehensive Cancer Center

Iressa (gefitinib)

Breast : Gefitinib has very little activity as a single agent in the overall breast cancer population, but preclinical data have suggested synergy with tamoxifen and other hormonal agents, as well as other growth factor inhibitors.
- A Pilot Trial Incorporating ZD1839 (IRESSA) into Adjuvant Therapy for Breast Cancer - BRE02-43. Hoosier Oncology Group
- Anastrozole With or Without Gefitinib in Treating Postmenopausal Women With Metastatic or Locally Recurrent Breast Cancer. EORTC
- Gefitinib With or Without Tamoxifen in Treating Patients With Tamoxifen-Resistant Metastatic Breast Cancer. No rris Cotton Cancer Center

Trastuzumab and Gefitinib in Treating Patients With Metastatic Breast Cancer. Eastern Cooperative Oncology Group (ECOG)

01-17-2006, 10:35 PM	#1
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	small molecule drugs: clinical trials We are all aware of the clinical trials with lapatinib but there are a few other small molecule HER inhibitors that are also undergoing clinical trials. The important thing about small molecule drugs is that they cross the blood / brain barrier. Al Tarceva (erlotinib) Erlotinib and Gemcitabine in Treating Patients With Metastatic Breast Cancer Previously Treated With An Anthracycline and/or a Taxane, North Central Cancer Treatment Group Erlotinib and Bevacizumab (avastin) in Treating Women With Stage IV Breast Cancer. Memorial Sloan-Kettering Cancer Center Trastuzumab and Erlotinib as First-Line Therapy in Treating Women With Metastatic Breast Cancer Associated With HER2/neu Overexpression. Jonsson Comprehensive Cancer Center Iressa (gefitinib) Breast : Gefitinib has very little activity as a single agent in the overall breast cancer population, but preclinical data have suggested synergy with tamoxifen and other hormonal agents, as well as other growth factor inhibitors. A Pilot Trial Incorporating ZD1839 (IRESSA) into Adjuvant Therapy for Breast Cancer - BRE02-43. Hoosier Oncology Group Anastrozole With or Without Gefitinib in Treating Postmenopausal Women With Metastatic or Locally Recurrent Breast Cancer. EORTC Gefitinib With or Without Tamoxifen in Treating Patients With Tamoxifen-Resistant Metastatic Breast Cancer. No rris Cotton Cancer Center Trastuzumab and Gefitinib in Treating Patients With Metastatic Breast Cancer. Eastern Cooperative Oncology Group (ECOG) __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.