[RobinP]

Al, thanks for the information regarding small studies and Avastin. I am ever hopeful that it newer and larger clinical trails will give Avastin a thumbs up. I certainly do see it as a potential drug in breast cancer treatment, particularly in syngery with other bc targeted regimens and chemotherapy.

I must say that you are very up on everything concerning her2 and treatments Al and I commend you for your knowledge and input on this site. I also believe that the day and age of emphirically administering various medications without known rationales is coming to an end, considering the proven benifit of targeted therapies. For example, Herceptin never would have been effective in the adjuvant trails if her2 was not screened for first. Lets hope for the long term success of other targeted bc drugs that are in trails now, like Lapatinib. Thanks God that pharmaceutical companies today are studying the histological make up of tumors and developing targeted drugs for those markers.

Steph, I am sorry to say that I do not have any book marks for p53, I know I read it recently but not sure where.

PS. To everybody who has asked, you must test your invasive tumor for these markers, not your blood.