There are additional studies
to support the idea of treating every week whether adjuvent or stage IV disease.
My clinical trial with Taxol, Navelbine and Herceptin was for weekly doses and the reason was the same as stated for this trial. It was hoped that this dosing would have better effect on hard-to-treat mets, and it sure did for mine. When you are bombarding the cancer cells with more than one way of killing them, it is best to get a little more of the drug by weekly dosing than less frequent dosing.
For instance when I had my Adriamycin weekly, I was getting more total drug per month than if I took it every two weeks.
And do not forget the drugs that are taken daily in pill form.
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