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Hi Liz:
I just got my first loading dose of Herceptin a few days ago. My biggest symptom was severe chills. I froze to death under a ton of blankets!
A friend of mine is just a couple of doses ahead of me and she also got the chills. Her solution has been to either sit in a hot bath or to nuke a seed bag and wear in against her body. She said that you definately need a source of heat during that phase. She also got severe pain in her knee joints.
Apparently the herceptin collects in the synovial fluid. You need to exercise your joints (ie walk) to express the herceptin out of your joints. I didn't get the joint pain myself, but she said that other people in her study got similar symptoms.
Regards,
Merridith
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