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al from Canada · 01-15-2006, 02:20 PM

Good thought Robin, the problem with many of these studies is that they don't address the other multitude of interactions that may cause PTEN inhibition or PI3K over-expression for that matter...and we know that cancer has many x-talk fail-safes. I mentioned PI3K because it keeps cropping-up over and over and over.....
Thanks for your info, Becky. Doesn't sound like selenium is the supplement of choice. We'll keep digging...

Here is a link to an excellent summary of PI3K actions and if you notice on the chart, IP6 is involved but it looks like it is downstreamstream, I'm not a biology person.
Misregulation of inositol signalling pathways has been implicated in a variety of diseases, including hypertension, diabetes and neuronal disorders, prompting the developmt of pharmacological agents that re-establish normal inositol signalling....inhibitors of PI3K are candidates for therapeutic agents for cancers and related metabolic diseases."

http://www.nyu.edu/classes/ytchang/r...d%20review.pdf

Regards,
Al

01-15-2006, 02:20 PM	#4
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	Robin and Becky, a great summary Good thought Robin, the problem with many of these studies is that they don't address the other multitude of interactions that may cause PTEN inhibition or PI3K over-expression for that matter...and we know that cancer has many x-talk fail-safes. I mentioned PI3K because it keeps cropping-up over and over and over..... Thanks for your info, Becky. Doesn't sound like selenium is the supplement of choice. We'll keep digging... Here is a link to an excellent summary of PI3K actions and if you notice on the chart, IP6 is involved but it looks like it is downstreamstream, I'm not a biology person. Misregulation of inositol signalling pathways has been implicated in a variety of diseases, including hypertension, diabetes and neuronal disorders, prompting the developmt of pharmacological agents that re-establish normal inositol signalling....inhibitors of PI3K are candidates for therapeutic agents for cancers and related metabolic diseases." http://www.nyu.edu/classes/ytchang/r...d%20review.pdf Regards, Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006. Last edited by al from Canada; 01-15-2006 at 02:27 PM..