[RobinP]

I have seen via of message boards and word of mouth, a number of people doing late herceptin. However, I have not found anyone who is doing it with chemotherapy or taxol. I think the general feeling is who wants to go through all that again when there is no proveth that Herceptin as a single agent is not as effective as with chemotherapy in the adjuvant setting. This is quite evident in the HERA trail where herceptin was given after chemo where the increased DFS was about the same as the NCI trails where Herceptin was given with chemotherapy. I also think a lot of women just don't want to go through chemotherpy again, loosing hair, feeling sick for weeks or months when they are NED and seemingly have no reason for it. I just don't see late herceptin trails with taxol as a happening thing; who would volunteer for it- not many.Also, doing more herceptin late is bad enough.Am I the only one feeling vulnerable and like a cancer patient all over again with the weekly or triweekly reminders of Herceptin?LOL.

Interesting thread AA, I wish some mets people here would contribute too on your inquiries about the efficacy of herceptin and taxol. Any takers???????????????