HER2 Support Group Forums - View Single Post - relevance of tumor markers discussed at SABC and herceptin

RobinP · 01-07-2006, 10:32 AM

If you have pTEN present, Herceptin activates it and in vitro proliferation events decrease. So you might say that pTEN presence may enhance the effectiveness of Herceptin. Again, Herceptin only acts to bind her2 only if you are truely positive and have an extrcellular domain for Herceptin to bind to. TAB250 tests for the presence of the extracellular domain-ECD of her2. Again, if you have the ECD present, you probably will respond to Herceptin. Herceptin binds to the cleaved her2 ECD to downregulate it. And if you don't have an ECD on her2 which is possible if you have the truncated form, p85, then Herceptin has nothing to bind to. Perhaps, Lapatinib, a small molecule then might be indicated since it works inside the her1 and her2 cell as oppposed to on the her2's ECD .

I used the following lab and had 6 biomarkers tested for on my stored tissue block from 3 years ago . But Michele used lab core.

Targeted Molecular Diagnostics
610 Oakmont Lane
Westmont, IL 60559
1-866-897-7350
http://www.tmdlab.com/
LOOk at this; it's interesting, really! http://www.wallstreetreporter.com/li...agnostics.html

01-07-2006, 10:32 AM	#7
RobinP Senior Member Join Date: Nov 2005 Posts: 943	Answers for what is TAB250 and where I had pTEN tested. If you have pTEN present, Herceptin activates it and in vitro proliferation events decrease. So you might say that pTEN presence may enhance the effectiveness of Herceptin. Again, Herceptin only acts to bind her2 only if you are truely positive and have an extrcellular domain for Herceptin to bind to. TAB250 tests for the presence of the extracellular domain-ECD of her2. Again, if you have the ECD present, you probably will respond to Herceptin. Herceptin binds to the cleaved her2 ECD to downregulate it. And if you don't have an ECD on her2 which is possible if you have the truncated form, p85, then Herceptin has nothing to bind to. Perhaps, Lapatinib, a small molecule then might be indicated since it works inside the her1 and her2 cell as oppposed to on the her2's ECD . I used the following lab and had 6 biomarkers tested for on my stored tissue block from 3 years ago . But Michele used lab core. Targeted Molecular Diagnostics 610 Oakmont Lane Westmont, IL 60559 1-866-897-7350 http://www.tmdlab.com/ LOOk at this; it's interesting, really! http://www.wallstreetreporter.com/li...agnostics.html __________________ Robin 2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo Last edited by RobinP; 01-07-2006 at 10:40 AM..