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Actually, Tamoxifen alone is a poor choice but not necessarily in combination with Herceptin. However, I believe that Herceptin and Arimidex is the best choice to avoid steric inhibition (meaning that you are trying to cover too many sites on the surface of a cancer cell with large macro molecules (ie: Herceptin and Tamoxifen). I think (and I only mean I think) that covering the Her 2 receptors with herceptin and then preventing estrogen formation with an AI is a better way to go. You also have to know that I am ER+ but PR neg and tamoxifen does not work well with people with that kind of pathology but AIs work excellent for that type of pathology (got my ovaries removed to utilize this technology). So for me, I am confident of the Arimidex/Herceptin regime I am on.
Please bear in mind this is only my opinion.
Best regards
Becky
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