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CherylS · 01-05-2006, 07:36 PM

If she is ER positive, tamoxifen is absolute standard of care for pre menopausal women, and has been for 20 years. Being HER2 positive and ER positive has nothing to do with reaction to chemo, except that the HER2 has been suspected of some resistance to chemo. Go to the home page of this website and you will find lots of info on HER2/NEU. The 3 + is a measurement based on the number of cells that expressed HER2 overamplificaiton. Again, DCIS means that no cancer left the duct. If it was in a lymph node, it left the duct. Not DCIS then, and if I am correct, the lymph node automatically warrants a stage 2 diagnosis.
Someone else may weigh in on this, but I'm pretty sure about that. Her pathology report should at least show HER2 amplificaiton, % of ER and PR positivity, tumor grade and tumor size.

There is something just not right about this doctor. Way too much time is passing and she needs to get on it now. Are you near a major hospital? That would probably be a good start for a referral. Otherwise a reputable cancer center.

Again, best wishes to her.

01-05-2006, 07:36 PM	#4
CherylS Senior Member Join Date: Oct 2005 Location: Minneapolis, MN Posts: 189	Wow, get her a new onc.! If she is ER positive, tamoxifen is absolute standard of care for pre menopausal women, and has been for 20 years. Being HER2 positive and ER positive has nothing to do with reaction to chemo, except that the HER2 has been suspected of some resistance to chemo. Go to the home page of this website and you will find lots of info on HER2/NEU. The 3 + is a measurement based on the number of cells that expressed HER2 overamplificaiton. Again, DCIS means that no cancer left the duct. If it was in a lymph node, it left the duct. Not DCIS then, and if I am correct, the lymph node automatically warrants a stage 2 diagnosis. Someone else may weigh in on this, but I'm pretty sure about that. Her pathology report should at least show HER2 amplificaiton, % of ER and PR positivity, tumor grade and tumor size. There is something just not right about this doctor. Way too much time is passing and she needs to get on it now. Are you near a major hospital? That would probably be a good start for a referral. Otherwise a reputable cancer center. Again, best wishes to her. __________________ Cheryl