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01-04-2006, 11:44 PM

Robin, I attended a lecture given by Dr. Ellie Guardino of Stanford wherein she quoted an experiment wherein they sucessively blocked the different ERRB receptors in mice with her2 positive tumors and once 1 through 3 were blocked the tumors disappeared and did not recur. At that time they thought her4 actually was protective against breast cancer (or "good"), which is no longer thought to be the case (I seem to rememberan article which proposed that there are various isoforms of her4 which encode proteins with different functions leading to different prognoses). In any case, I will look for an article which fits the above description and get back to you if I find it.

01-04-2006, 11:44 PM	#2
Lani Guest Posts: n/a	lapatinib+pertuzamab+Herceptin combo Robin, I attended a lecture given by Dr. Ellie Guardino of Stanford wherein she quoted an experiment wherein they sucessively blocked the different ERRB receptors in mice with her2 positive tumors and once 1 through 3 were blocked the tumors disappeared and did not recur. At that time they thought her4 actually was protective against breast cancer (or "good"), which is no longer thought to be the case (I seem to rememberan article which proposed that there are various isoforms of her4 which encode proteins with different functions leading to different prognoses). In any case, I will look for an article which fits the above description and get back to you if I find it.