HER2 Support Group Forums - View Single Post

StephN · 12-20-2005, 10:46 PM

Hi Rich -
Maybe most docs would want to reconfirm for HER2 by FISH if the IHC was only ++ or less, but if it is +++ by IHC we get Herceptin.

I was HER2+++ by IHC at my diagnosis and have never had the FISH, even for my mets. I have responded well on Herceptin and that seems to be good enough for my med onc.

It seems that a very positive IHC indicates high overexpression and we go from there. But it would be interesting to know my FISH number - just to go with all the other numbers in my life!!

12-20-2005, 10:46 PM	#17
StephN Senior Member Join Date: Nov 2004 Location: Misty woods of WA State Posts: 4,128	IHC +3 - do not need FISH Hi Rich - Maybe most docs would want to reconfirm for HER2 by FISH if the IHC was only ++ or less, but if it is +++ by IHC we get Herceptin. I was HER2+++ by IHC at my diagnosis and have never had the FISH, even for my mets. I have responded well on Herceptin and that seems to be good enough for my med onc. It seems that a very positive IHC indicates high overexpression and we go from there. But it would be interesting to know my FISH number - just to go with all the other numbers in my life!!