[RobinP]

Yes, I did realize the study group by Tham was pre-Herceptin days. And it would be interesting to know what had happened if this study had taken Herceptin. I have read an article by Martine Piccart, PI of the HERA trail, that indicated that in the mets. populatioin, those who have been treated with herceptin, should they have a brain mets later, have a better OS survival with a brain mets than those never having had hercetpin. Her conclusion was that herceptin itself helped to make the disease less aggressive in the brain; interesting!