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Michele;
They get the 2x more likely to get brain mets because there were 2x more her2 positive people than would have be expect if the ratio of her2+/her neg had remained the same as that seen in the non metastatic population.
for example:
if you had 60 early stage BC patients you would expect to find 15 of them her2+ (eg.25% ==1/4).
if the her2+ and her2 neg patients all went on to develop brain mets at the same rate then the 1/4 ratio should be maintained. So if you had 60 people with brain mets only 15 of them would be expected to be her2+ but what they found was that 34 of the 60 were Her2+-- eg. there were twice as many as expect if the two populations had the same level of risk.
kk1
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