HER2 Support Group Forums - View Single Post - joint pain from arimidex or from histerectomy

12-11-2005, 03:59 PM

I should have included this before.

Its back to the old chestnut omega three and six. There is a lot of material on omega three and omega six and arthritis. Omega six fuels the eicosanoid pathway, and produces cox 2 amongst other things, which are recognised imflamatory agents. See the post on articles of interest "The importance of omega three and six to breast cancer".

It is arguably fundmental in nutritional terms to balance omega three and six intakes. For most diets this would include taking fish oils/ maybe flax, and cutting down strongly on sixes using olive oil where you might have used high six oils like soy corn sunflower safflower etc.

If you have not read the related posts on omega three, olive oil etc my personal view on balance would be that it should come at the top of the diet research list.

Here is a link that may help start you in that direction.

As ever you are best checking the links and doing some research yourself for your own circumstances.

http://www.ncbi.nlm.nih.gov/entrez/q...739&query_hl=2

ABSTRACT

1: Nutrition. 2005 Feb;21(2):131-6. Related Articles, Links
Click here to read
Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.

Berbert AA, Kondo CR, Almendra CL, Matsuo T, Dichi I.

Department of Department of Pathology, Londrina State University, Parana, Brazil.

OBJECTIVE: This study evaluated whether supplementation with olive oil could improve clinical and laboratory parameters of disease activity in patients who had rheumatoid arthritis and were using fish oil supplements. METHODS: Forty-three patients (34 female, 9 male; mean age = 49 +/- 19y) were investigated in a parallel randomized design. Patients were assigned to one of three groups. In addition to their usual medication, the first group (G1) received placebo (soy oil), the second group (G2) received fish oil omega-3 fatty acids (3 g/d), and the third group (G3) received fish oil omega-3 fatty acids (3 g/d) and 9.6 mL of olive oil. Disease activity was measured by clinical and laboratory indicators at the beginning of the study and after 12 and 24 wk. Patients' satisfaction in activities of daily living was also measured. RESULTS: There was a statistically significant improvement (P < 0.05) in G2 and G3 in relation to G1 with respect to joint pain intensity, right and left handgrip strength after 12 and 24 wk, duration of morning stiffness, onset of fatigue, Ritchie's articular index for pain joints after 24 wk, ability to bend down to pick up clothing from the floor, and getting in and out of a car after 24 wk. G3, but not G2, in relation to G1 showed additional improvements with respect to duration of morning stiffness after 12 wk, patient global assessment after 12 and 24 wk, ability to turn faucets on and off after 24 wk, and rheumatoid factor after 24 wk. In addition, G3 showed a significant improvement in patient global assessment in relation to G2 after 12 wk. CONCLUSIONS: Ingestion of fish oil omega-3 fatty acids relieved several clinical parameters used in the present study. However, patients showed a more precocious and accentuated improvement when fish oil supplements were used in combination with olive oil.

Publication Types:

* Clinical Trial
* Randomized Controlled Trial

PMID: 15723739 [PubMed - indexed for MEDLINE]

12-11-2005, 03:59 PM	#3
Unregistered Guest Posts: n/a	I should have included this before. Its back to the old chestnut omega three and six. There is a lot of material on omega three and omega six and arthritis. Omega six fuels the eicosanoid pathway, and produces cox 2 amongst other things, which are recognised imflamatory agents. See the post on articles of interest "The importance of omega three and six to breast cancer". It is arguably fundmental in nutritional terms to balance omega three and six intakes. For most diets this would include taking fish oils/ maybe flax, and cutting down strongly on sixes using olive oil where you might have used high six oils like soy corn sunflower safflower etc. If you have not read the related posts on omega three, olive oil etc my personal view on balance would be that it should come at the top of the diet research list. Here is a link that may help start you in that direction. As ever you are best checking the links and doing some research yourself for your own circumstances. http://www.ncbi.nlm.nih.gov/entrez/q...739&query_hl=2 ABSTRACT 1: Nutrition. 2005 Feb;21(2):131-6. Related Articles, Links Click here to read Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Berbert AA, Kondo CR, Almendra CL, Matsuo T, Dichi I. Department of Department of Pathology, Londrina State University, Parana, Brazil. OBJECTIVE: This study evaluated whether supplementation with olive oil could improve clinical and laboratory parameters of disease activity in patients who had rheumatoid arthritis and were using fish oil supplements. METHODS: Forty-three patients (34 female, 9 male; mean age = 49 +/- 19y) were investigated in a parallel randomized design. Patients were assigned to one of three groups. In addition to their usual medication, the first group (G1) received placebo (soy oil), the second group (G2) received fish oil omega-3 fatty acids (3 g/d), and the third group (G3) received fish oil omega-3 fatty acids (3 g/d) and 9.6 mL of olive oil. Disease activity was measured by clinical and laboratory indicators at the beginning of the study and after 12 and 24 wk. Patients' satisfaction in activities of daily living was also measured. RESULTS: There was a statistically significant improvement (P < 0.05) in G2 and G3 in relation to G1 with respect to joint pain intensity, right and left handgrip strength after 12 and 24 wk, duration of morning stiffness, onset of fatigue, Ritchie's articular index for pain joints after 24 wk, ability to bend down to pick up clothing from the floor, and getting in and out of a car after 24 wk. G3, but not G2, in relation to G1 showed additional improvements with respect to duration of morning stiffness after 12 wk, patient global assessment after 12 and 24 wk, ability to turn faucets on and off after 24 wk, and rheumatoid factor after 24 wk. In addition, G3 showed a significant improvement in patient global assessment in relation to G2 after 12 wk. CONCLUSIONS: Ingestion of fish oil omega-3 fatty acids relieved several clinical parameters used in the present study. However, patients showed a more precocious and accentuated improvement when fish oil supplements were used in combination with olive oil. Publication Types: * Clinical Trial * Randomized Controlled Trial PMID: 15723739 [PubMed - indexed for MEDLINE]