HER2 Support Group Forums - View Single Post

al from Canada · 12-10-2005, 09:34 PM

Dear Lyn,

There are a number of situations were I would consider a clinical trial, such as;
1. if I had developed a resistance to other chemos and / or herceptin,
2. if I had metastatic disease that was stable and
3. if it were a targetted therapy that was concurrent with herceptin.

I would not go into the trial if I had active disease that was responding to treatment or if I were on a proven therapy such as herceptin nd asked to abandon it for the experimental drug. I would keep in mind that HER2 disease is VERY specific and requires VERY targetted therapies to get a positive response. I would also consider treatments for the other over-expressed pathways which are bound to HER2 over-expression, suchas as P13K inhibitors, HER1 inhibitors, COX2 inhibitors and VEGF inhibitors.
Regards,
Al

12-10-2005, 09:34 PM	#8
al from Canada Senior Member Join Date: Jul 2005 Location: Ontario, Canada Posts: 722	What SABCS would suggest Dear Lyn, There are a number of situations were I would consider a clinical trial, such as; 1. if I had developed a resistance to other chemos and / or herceptin, 2. if I had metastatic disease that was stable and 3. if it were a targetted therapy that was concurrent with herceptin. I would not go into the trial if I had active disease that was responding to treatment or if I were on a proven therapy such as herceptin nd asked to abandon it for the experimental drug. I would keep in mind that HER2 disease is VERY specific and requires VERY targetted therapies to get a positive response. I would also consider treatments for the other over-expressed pathways which are bound to HER2 over-expression, suchas as P13K inhibitors, HER1 inhibitors, COX2 inhibitors and VEGF inhibitors. Regards, Al __________________ Primary care-giver to and advocate for Linda, who passed away April 27, 2006.