[al from Canada]

Hey Tom,
These stats were accumulated from a patient population base dating from long before there as any test for HER2 or herceptin or tamoxifen or AI's and certainly doesn't address the question of statistical significance on BC patients receiving herceptin. Most of these cancers have very high EGF, HER1, HER2, HER3 and sometimes hormonal expressions. So the retorical question is, did they do a FISH or IHC on these secondary cancers, did they separate the HER2 population from their stats, What was the secondary cancer rates on people using tamoxifen, etc.
I think we have to stay focused on the fact that HER2 BC should be treated as a completely different type of cancer....... as is being confirmed by everything I'm hearing at SABCS. That said, sun block SPF 30 -45 is manditory for BC girls, especially if they are on chemo.

From chilly S.A. (freezing drizzel last night)
Al