My very limited experience is the more you read and delve the more your realise how complex it all is, how many mechanisms are involved, the multi layered multipathway, multi mechanism nature of it all.
You also begin to realise how much the scientific community does not know.
It is truly wonderous what they have found but it looks like a very long way to go yet. As the article says;
"Dr. Toker said this research "once again reminds us of the immensely complex nature of molecular events which govern the behavior of cancer cells. Proteins such as Akt, which at first glance seemingly control only one aspect of a cancer cell's life, actually have multiple functions."
I looked up ACT and breast cancer on google. As usual fro any such subject a heap of links.
Here are a couple;
http://www.medscape.com/viewarticle/503916_9
ABSTRACT
"Mammalian Target of Rapamycin and the PI3K/Akt Pathway
The PI3K pathway is involved in regulating multiple cellular functions important for cell survival and proliferation. Signaling through Akt regulates the serine-threonine kinase mammalian target of rapamycin (mTOR). mTOR is involved in transcriptional and translational regulation proteins important to regulation of the cell cycle. In breast cancer, the PI3K/Akt/mTOR pathway can be activated by the ER, the IGF-1 receptor, and the HER family, especially HER3. Oncogenic ras is another stimulator of this pathway.[46] Also, in a study of 70 primary breast cancer specimens, 40% had an activating mutation in the PI3KCA gene.[47"
AND if you really wan't to end up "scratching your head" how about this?
http://clincancerres.aacrjournals.or...tract/9/8/2933