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Dr. Rose's paper based on hormone negative human her2+ cells implanted in mice
MDA-MB-435 stands for human breast cancer cells which were injected into mice to do these experiments. It is a line of breast cancer cells named after its hospital of origin (MD Anderson) which has been perpetuated and used in experiments the world over. It is her2neu positive and estrogen-independent and expresses LH-RH (luteinizing hormone-releasing hormone receptors) among other things.
ONE may not be able to extrapolate from this experiment with human breast cancer cells implanted in mice what happens in people and certainly not those with her2 positive tumors which are also hormone receptor positive. Dr. Stephanie Jeffreys of Stanford University has identified three different groups of her2+ hormone+ tumors by gene signature (multi gene array), each with a different behavior.
As is usual, no simple answers unfortunately.
Hope this helps ( even if it is frustrating to realize that there is so much more that is not known than is known!)
Lani
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