I'm looking for opinions. I am currently on 60 mg of Phenobarbital for epilepsy (haven't had a seizure in years and those were only petite mal) and when trying to figure out if THIS drug could increase my liver enzymes, I found that it could, especially the GGT. I ALSO found out that this is also of the class of drugs called CYP 450 3A4 inducers which "CYP450 enzymes can be induced by drug treatment which may cause formation of toxic metabolites and/or decreased systemic drug levels resulting in loss of efficacy."
Should I:
A: stop taking it and pray I don't get another seizure
B: look for an alternative drug (any suggestions)
C: any other ideas
I am on Herceptin (I was dx 2/1/05 w/ Stage 1, Grade 3, no nodes, partial mastectomy on 2/7/05, finished 6 rounds of dose dense TEC on 5/18/05, finished 33 rads on 8/1/05, started every 3 week for 1 year Herceptin 8/18/05.
CYP450 3A4 inducers, including:
carbamazepine
phenobarbital
phenytoin
rifabutin
rifampin
rifapentine
St John's wort
Thank you.
Rhonda Hoffman
