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Suggestions
Perhaps you could try Fulvestrant. It works via a totally different mechanism of action than tamoxifen or raloxifene (which block the estrogen receptor) or the AIs which block an enzyme which converts precursors to estrogen in post-menopausal women in an effort to "starve" the estrogen receptor of its ligand.
Unfortunately breast cancer cells have their OWN estrogen factory which uses one of THREE different enzymes to make estrogen and AIs only block one of these.
Fulvestrant binds to the estrogen receptor and then degrades it PERMANENTLY.
Unfortunately it does this not only on breast cancer cells, but on all cells containing estrogen receptors. Not a big problem for someone like you who has withstood multiple chemotherapy regimens.
I have posted in other threads at least four articles on the use of fulvestrant and will again if you let me know that you can't find them.
In addition, unless you have lost a lot of weight, it might be interesting to try Xenical, a weight loss medication made by Roche (who market Herceptin in Europe).
I don't think it could hurt unless you forgot to take your fat soluble vitamins (Vitamins A,D,E, and K) several hours before or after you took your Xenical
or if you got very dehydrated by diarrhea, which I am quite sure you could look out for and avoid. Also you would have to remember to take your flaxseed oil, evening primrose oil, and/or olive oil simultaneously ( with similar timing as that described above)
The article, based on in vitro experiments (in the lab, not in live humans) has shown strong synergy with Herceptin.
I am posting the reference:
: Menendez JA, Vellon L, Lupu R. Related Articles, Links
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
Ann Oncol. 2005 Aug;16(8):1253-67. Epub 2005 May 3.
PMID: 15870086 [PubMed - in process]
I will post the abstract in my next post--I am always losing my efforts when attempting to switch between programs and cut and paste--
What could be better than fighting your breast cancer and becoming "svelt"
in one fell swoop! ( I hope the chemo has not left you overly thin preventing you from trying this option). This may be an unorthodox option, but if it might work....!
Hope these ideas help!
LANI
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