Evening primrose oil GLA
I have read the summary of the trial.
It was conducted in "vitro". It is interesting.
BUT the mechanisms are complex. GLA can be made in the body from linoleic acid omega six. There is a theory that some people cannot make GLA effectively and that is why it helps, but it is likely to be more complex.
In a trail with rats a proportion of the GLA was absorbed into the cells, but most was used in the linoeic acid chain and converted to Arachidonic Acid AA.
Omega six is used to produce GLA and later down the path AA which in turn is used to produce prostaglandins and Cyclo-oxegenase (COXs) as part of very complex and subtle mechanisms.
There is concern that overproduction may be a percussor of cancer amongst other things.
So caution would probably best the best advice, as intake in foods of all linoleic acids and derivatives should be considered as a whole. Please see the posts on the Articles of Interest which may help explain.
RB
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