[Christine]

Hi Linda

I never had the FISH test, since this assay test was not yet given. This test measures the entire her2 protein therefore showing the pathologist the real count under a microscope. I was determind to be a strongly 3+ and I proved to be so. Herceptin in 1 infusion helped me tremendously. I was stage 4 with a fluid filled lung that all went away in 3 days. I feel it is a very accurate test; and never found it necessary to go for the FISH assay test. However it is a test to have to determine the DNA her2neu status+ or -and is necessary test to have to enter most clinical trials. After my battle with brain metastases, I feel herceptin continues to help me stay NED. ihc WORKED FOR ME, AND I DO UNDERSTAND THAT FALSE + OR - exists so that is why I feel at the time of biopsy both tests should be performed especially if one test alone results in a negative her2 result.
I wondered as I was reading your post if you had taken herceptin for a few rounds before repeating the her2 test. That would definitly give you a false negative. Being + and then - is unusual: it's usually the other way arround( - to +). Those tested - usually test again to find out it can be a different result. being +++ is actually a great reult to have with herceptin beiing your most powerful weapon along with another chemo (there are many compatible chemotherapy's. I would definitely like to know which of the two tests is right? Ask for a retake. Your Onc should understand.
So I felt you should know my story. Warm Hugs, Christine