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Hi:
From what I understand, if you are negative for FISH, you will not benefit from Herceptin.
In my case, I believe the original small hospital lab made a mistake on my IHC test. I don't think I was ever a 3+. There are a lot of varibles in the IHC test that can cause a wrong result.
Although rare to have an incorrect positive IHC, it happened to me and I know of another person who was labeled IHC3+ but negative for FISH.
In my opinion, there is a way to double check the IHC test, which would be FISH. I think the clinical trial subjects all were confirmed Her2+ by FISH. Unfortunately, the FISH test is expensive and time consuming so it is not routinely done.
I almost went through a whole year of Herceptin which would have been of no benefit to me. My result was 1.5 by FISH.
To give myself some peace, I am going to have both tests done again!
Linda
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