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My two cents...without reading the whole article yet, I think Celebrex and its analogues are probably working on inhibiting the cox-2 mechanism. Studies indicate that her-2 mediated cancers have tons of cox-2. Would love to learn more about this topic as it and the glutamate are tying into my own research at unexpected points. Many thanks for these great articles, Al. Fyi, Gina
P.S. Barbara, if it really is the cox-2 mechanism involved and not something more complex..do not worry, your Celebrex inhibits cox-2 just as well or even better than some of the analogues --of course the role of cox -2 in cancer continues to be debated feverishly...smile..like so much else. My onc was just up in New York for that big her-2 conference and she came back disheartened that there is still not a lot of reliable data on what causes her-2 and how best to combat it and said there was even a lot of disagreement among oncs about how to use herceptin, whether to follow markers or not, what, if any role antibiotics can play, etc. In the end, she said she was putting her money on clinical experience as she thinks the clinicians are going to learn best how to use herceptin by simply using it long before the science - types figure it all out...hmmm...she may be right, although I hope science can help us out SOONER rather than later...smile-GP
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