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Hi Lisa,
From what I've learned there is no guarantee that A/C is going to be effective either, so how long do you wait before switching to another treatment while on A/C? All new treatments start out in clinical trials in the metastatic setting and work their way up to primary adjuvant therapy just like A/C did at one point to replace CMF. So, when the taxanes proved effective in the metastatic setting, they became an add-on to A/C. They really are similar in terms of efficacy, the beauty is sometimes when A/C doesn't work, taxanes will, or vice versa due to the lack of cross resistance.
With all the recent positiive data about combining Herceptin and a taxane, oncologists are starting to use this as a first line therapy for Her2 positiive women.
Best of luck,
Scott
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