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Here's how I understand it:
Because of cross-talk between HER2 and Estrogen receptors, the body develops tam. resistance. This can be reversed with a tyrosine kinase inhibitor such as Lapatinib or Iressa. There is also a theory that Herceptin + tam. may actually make the cancer wworse but the jury is still out on that one. I would get something to shut down your ovaries and go with the A.I. such as arimidex...that has a proven level of effacy far greater than tam + herceptin.
Regards,
Al
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