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Vinnie:
My wife's situation is very similar to your's (Her2/neu and er+/pr+, oophorectomy). We can't get much info from the doctors if they feel one is superior to the other, but from what I've seen on the internet Femara(Letrozole) is more potent than Arimidex(Aromasin). Whether that translates into any additional
benefit remains to be seen as Arimidex shuts down estrogen production from androgen conversion by 97%. Letrozole is 99% effective. The estrogen suppression may reach a point where more is not necessarily better and may have more long term side effects we don't know about yet.
If my wife wasn't Her2/neu I may go with Arimidex as there is more safety data available and they have similar overall efficacy, but all the trials seem to combine Letrozole with Herceptin or Lapatinib. So I'm going to gamble that Letrozole may have a slight advantage over Arimidex in our situation. I'm also keeping my eye on GSK's Lapatinib application for FDA approval later this year as Herceptin can't be taken long term and requires an infusion, while Lapatinib is more effective and is a daily pill.
Please post back if you find any more info.
Thanks and good luck,
Scott
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