Hi Michele, you sound very strong and focused and that's very good as that attitude will help keep your immune system strong. You say you're taking a lot of supplements, so I hope you've discussed what you're taking in conjunction with chemo with your onc. There are some antioxidants that are considered to be counterproductive to chemo, you've probably heard this but it's worth consideration. Here's a link to an interesting article on this subject; I haven't read the whole thing, but found it thought provoking.
http://www.lef.org/protocols/prtcls-...prtcl-024.html
So sorry you're having such a rough time getting the breast tissue to respond; I do agree a second opinion may be warranted. But remember, the breast tissue concerns are not as dangerous as the brain mets, that has to be brought under control and then you can deal with the rest. Maybe bi-lateral mastectomy, reconstruction at a later date after you've reached NED, which we hope and pray for.
Love, Lolly