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Hi Velva- I have had the most success with Herceptin/Avastin. This combo reduced the skin mets almost 90%. The large internal tumor in my right breast hasn't shrunken as much though. Its has gotten softer around the edges but the nipple is retracting. The doctors aren't sure if it is better or worse. Good luck and happy holidays. The best of health to you. Regards, Carol
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