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Kitty, your response of "if there will be a recurrence, but when" is precisely why I'm asking. My wife is also ER-/PR- and she will be going onto herceptin off protocol after radiation. Although I am thankful that herceptin is available I would feel more comfortable if she was taking it along with her chemo (did AC and now on Taxol), since it has been found to be more effective that way (in metastatic setting). Since she has been on a dose dense schedule (every other week rather than once every 3 weeks), she was not eligible for a herceptin trial and her onc was concerned with toxicity. I am searching for stats to help us determine how agressive we really need to be in preventing any recurrence. If it turns out that the odds favor no recurrence then the herceptin alone may be enough. If the odds are heavily stacked against her then we would push for something more. FYI...7 pos nodes, er-/pr-, and her2 overexpressed. Thanks, Eric
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