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Hi Eugene,
I agree with Carlye, it would be wise to look for a doctor who is open to the idea of Herceptin off-protocol. Since your wife is Her2+, ER/PR- with positive nodes, her chance of recurrence is higher.
I was Stage 3b, Her2+, ER/PR- with 5 of 5 positive nodes, so my situation was more grave than your wife's, but in hindsight would have pushed for Herceptin off-protocol had I known then what I know now.
Best Wishes, Lolly
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