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I get weekly herceptin and will eventually go to the 3 week dose you describe. Usually the flu-like symptoms only appear with the very first dose, which is a "loading dose." I had 102 degree fever and chills for 3 days after that first dose! My doctors pre-treat me with tylenol (625 mg) and benadryl (25 mg in the IV) before I get my herceptin. Since the first treatment, I've not had any bad effects from the herceptin at all. Good luck.
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