HER2 Support Group Forums - View Single Post - Relationship between HER-2 and BRCA1 & 2

06-07-2004, 04:50 AM

My late wife died of metastaic breast cancer in the pre Herceptin era. She was HER-2 positive. She left two daughters who are now young women, 24 and 19 years of age. Recently, I have read of the disproportionately high incidence of breast and ovarian cancer at all ages for women who have either the BRCA 1 or BRCA2 gene.
Can anyone tell me whether there is a correlation between tumors that have excess HER-2 and the presence of either of the BRCA genes? If that is the case, I ought to let the girls know. Perhaps, they will want gene testing.

06-07-2004, 04:50 AM	#1
Leonard Guest Posts: n/a	My late wife died of metastaic breast cancer in the pre Herceptin era. She was HER-2 positive. She left two daughters who are now young women, 24 and 19 years of age. Recently, I have read of the disproportionately high incidence of breast and ovarian cancer at all ages for women who have either the BRCA 1 or BRCA2 gene. Can anyone tell me whether there is a correlation between tumors that have excess HER-2 and the presence of either of the BRCA genes? If that is the case, I ought to let the girls know. Perhaps, they will want gene testing.