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There is so much to say on each topic, easy to forget to add important info.
When mets are discovered in the body from the neck down, routinely a brain MRI is done to rule out mets there. Any med onc worth his salt will have this done so that the entire extent of mets is understood before embarking on a new treatment plan.
All clinical trials require that mets to the brain be ruled out before a patient is accepted. (This was so in my case.)
So, the answer is that when mets are being treated, it should already be determined that there is no spread in the brain area. And the reason for this is something called the "blood/brain barrier." This means that many molecules are too large to pass into the brain - as a natural protectant. Chemo does not breach this barrier normally.
Hope this clears up your question.
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