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Dear, you have been through a LOT lately, and I am sorry to hear about this.
Ask your onc to discuss about your tolerance on increasing side effects, h/she may give you different and better meds. Then with new meds, you may feel better / energetic to get around.
Effective treatment versus quality of life really boils down to the individual's own perspective, and there is no rulebook to have a guide about this. Please listen to your inner voice, and talk with your family / friends about your feelings. You own your body, and nobody knows it better than you.
God bless...
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