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Lisa, I have been on zometa for almost FOUR years. At times, my onc experimented with increased doses trying to keep my bone met stable. We have been very careful. I take it in a liter of fluid given over 2-3 hours instead of the usual 15 minute infusion. My onc also checks my creatinine ( a blood test ) before each dose of zometa.
In addition, because we were trying higher than usual doses, he followed something called a 24 hour urine for creatinine clearance. It is more sensitive than the regular blood test. At one point it did drop, so we backed off on the dose and it came back up.
I think if it is given carefully and slowly with close monitoring of kidney function, it can be safe. As I say, 4 years and still have normal kidney function.
Good luck.
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