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I don't remember if I had Benedryl with my first Herceptin infusions, but must have had, but I don't get any now, I know for sure. I've just had stomach issues with Navelbine, so I get Kytril with each infusion, and I have Phenergan pills here at home for breakthrough nausea. I didn't know Phenergan was also used for allergic reactions, but I looked it up after reading your post, and so it is...we just keep learning from each other!
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