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10-11-2004, 02:05 AM

Patty,

Thanks. I will do some further research on some of the things you mentioned. I'm sure they will come up with some ways to deliver drugs to the brain or drugs that are small enough molecules to get through the barrier at some point in the future. Unfortunately for my wife and I it will be too late.

As for Thalidomide, we did look into getting Barb into a clinical trial at Moffitt Cancer Center in Tampa where they were using Temodar and Thalidomide in combination but the Thalidomide dose was so large that it was scary. So I asked her medical onc's opinion and he said "Oh my god, that will kill her or damage her significantly within a week or will make her a zombie, it will be a nightmare!" Everyone should always evaluate any clinical trial very carefully even though it is sponsored by a major and respected cancer center, no matter how desparate you may be at the time. So we opted for the Temodar treatments only without the Thalidomide. When you get to the end stages the quality of life becomes a major issue even if you were willing to put up with a lot of side-effects as you were fighting or struggling with the cancer.

Thanks again for the info.

Larry

10-11-2004, 02:05 AM	#2
Larry Guest Posts: n/a	Patty, Thanks. I will do some further research on some of the things you mentioned. I'm sure they will come up with some ways to deliver drugs to the brain or drugs that are small enough molecules to get through the barrier at some point in the future. Unfortunately for my wife and I it will be too late. As for Thalidomide, we did look into getting Barb into a clinical trial at Moffitt Cancer Center in Tampa where they were using Temodar and Thalidomide in combination but the Thalidomide dose was so large that it was scary. So I asked her medical onc's opinion and he said "Oh my god, that will kill her or damage her significantly within a week or will make her a zombie, it will be a nightmare!" Everyone should always evaluate any clinical trial very carefully even though it is sponsored by a major and respected cancer center, no matter how desparate you may be at the time. So we opted for the Temodar treatments only without the Thalidomide. When you get to the end stages the quality of life becomes a major issue even if you were willing to put up with a lot of side-effects as you were fighting or struggling with the cancer. Thanks again for the info. Larry