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Hey A.A.
I think, from my quick searches, that there is a decent amount of interest in er+/her2+ not because it is such a rare combination, but because it is so (relatively) target-able. There are a bunch of folks trying to figure out the best combination of therapies for the targets.
That said, I also think that there is some theoretical work being done that suggests that things out there like gefinitib (and maybe herceptin) might ultimately be used in er-/pr- women to somehow create receptor positivity and then give the person hormonal options...
Best,
Jeff
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