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Becky · 07-29-2019, 07:17 AM

Affinitor is used in combination with Aromosin because in ER+/Her2 negative bc when Armidex or Femara has failed. It's the way the study was run and nothing more. Generally, the biochemical reaction in the body to inhibit the conversion androgens to estrogen is by inhibiting aromotase ( the catalyst for this reaction). Armidex and Femara use the same mechanism for this. Aromosin inhibits in a different mechanism.

I think your Xeloda question has a similar answer. Xeloda inhibits the synthesis of dna by inhibiting a chemical needed. It works differently than the other drugs mentioned and so the combo has a bigger punch by shutting down multiple mechanisms on reproduction.

07-29-2019, 07:17 AM	#3
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: Why Capecitabine and Exemestane? Affinitor is used in combination with Aromosin because in ER+/Her2 negative bc when Armidex or Femara has failed. It's the way the study was run and nothing more. Generally, the biochemical reaction in the body to inhibit the conversion androgens to estrogen is by inhibiting aromotase ( the catalyst for this reaction). Armidex and Femara use the same mechanism for this. Aromosin inhibits in a different mechanism. I think your Xeloda question has a similar answer. Xeloda inhibits the synthesis of dna by inhibiting a chemical needed. It works differently than the other drugs mentioned and so the combo has a bigger punch by shutting down multiple mechanisms on reproduction. __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"