HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Hi,

Just saw your question. I'm glad to hear 200 mg was well-tolerated. The only other high dosage I heard of was in the IT Herceptin trial that is ongoing. The dosage I heard of was 80 mg twice a week, which is somewhat comparable to 200 mg in a week.

-A

__________________

Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall.
Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy.
7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED.
10/27/15 atypical uptake in right cerebellum - inflammation?
12/1/15 Leptomeningeal dx. Starting IT Herceptin.
1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly
3/2016 - stable scan
5/2016 stable scan
7/2016 pseudoprogression?
9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT
11/2016 Cyberknife to temporal lobe, HBOT just prior
12/2016 - lesions starting to show shrinkage
8/2017 - Stable since Dec 2016. Temporal lobe lesion gone.
Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing.
Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.

05-11-2016, 09:20 AM	#208
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase Hi, Just saw your question. I'm glad to hear 200 mg was well-tolerated. The only other high dosage I heard of was in the IT Herceptin trial that is ongoing. The dosage I heard of was 80 mg twice a week, which is somewhat comparable to 200 mg in a week. -A __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.