HER2 Support Group Forums - View Single Post - determining which patients benefit from more than 5 years of antihormonal therapy--

Jean · 03-23-2014, 08:26 PM

Hi Becky like you this is my 9th year on AI (Femara)
being Estrogen 90%
highly Her2 positive
OncotypeDX was high also ....so for me it was not requiring brain surgery to continue on Femara past 5 yrs.
My concern is next year....after yr.10

http://www.medicalnewstoday.com/releases/274300.php?tw

From article:

"We are about to start a trial called IBIS-3 of extended therapy with aromatase inhibitors in long-term survivors with ER+ breast cancer with other unfavourable characteristics, and also adding new drugs used in other conditions that show promise in preventing breast cancer recurrence - a bisphosphonate (bone sparing drug) and metformin (diabetes drug). Hopefully, this biomarker work will help to pinpoint more accurately which patients need additional treatment."

I am thinking I woud like to take part in this trial.
I am seeing my onc. early April and will discuss this but I am fairly certain i will hear that "we just don't know"
What are your thoughts Becky?
Hugs dear sister,
Jean

03-23-2014, 08:26 PM	#4
Jean Senior Member Join Date: Oct 2005 Location: New Jersey Posts: 3,154	Re: determining which patients benefit from more than 5 years of antihormonal therapy Hi Becky like you this is my 9th year on AI (Femara) being Estrogen 90% highly Her2 positive OncotypeDX was high also ....so for me it was not requiring brain surgery to continue on Femara past 5 yrs. My concern is next year....after yr.10 http://www.medicalnewstoday.com/releases/274300.php?tw From article: "We are about to start a trial called IBIS-3 of extended therapy with aromatase inhibitors in long-term survivors with ER+ breast cancer with other unfavourable characteristics, and also adding new drugs used in other conditions that show promise in preventing breast cancer recurrence - a bisphosphonate (bone sparing drug) and metformin (diabetes drug). Hopefully, this biomarker work will help to pinpoint more accurately which patients need additional treatment." I am thinking I woud like to take part in this trial. I am seeing my onc. early April and will discuss this but I am fairly certain i will hear that "we just don't know" What are your thoughts Becky? Hugs dear sister, Jean __________________ Stage 1, Grade 1, 3/30/05 Lumpectomy 4/15/05 - 6MM IDC Node Neg. (Sentinel node) ER+ 90% / PR-, Her2+++ by FISH Ki-67 40% Arimidex 5/05 Radiation 32 trt, 5/30/05 Oncotype DX test 4/17/06, 31% high risk TOPO 11 neg. 4/06 Stopped Arimidex 5/06 TCH 5/06, 6 treatments Herceptin 5/06 - for 1 yr. 9/06 Completed chemo Started Femara Sept. 2006