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Rolepaul · 01-21-2013, 10:43 AM

Tykerb and Xeloda do pass the BBB. Herceptin does not in therapeutic amounts. Gamma Knife and IMRT will continue to be a first line therapy as they are less costly and can provide an immediate response that is measurable in a month. Intrathecal Herceptin is not widely in place yet. It is costly and requires weekly visits. I think if the lesions are not kept under control with WBR and/or Tykerb/Xeloda, then the IT Herceptin is the path to go.

01-21-2013, 10:43 AM	#31
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 391	Re: brain mets Tykerb and Xeloda do pass the BBB. Herceptin does not in therapeutic amounts. Gamma Knife and IMRT will continue to be a first line therapy as they are less costly and can provide an immediate response that is measurable in a month. Intrathecal Herceptin is not widely in place yet. It is costly and requires weekly visits. I think if the lesions are not kept under control with WBR and/or Tykerb/Xeloda, then the IT Herceptin is the path to go.