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phil · 12-10-2012, 08:55 AM

In the expanded access there are 2 dose reductions, to 3.0 from 3.6 then to 2.4 . Lorraine is hanging in at 3.0 for well over a yr, 2 yrs on drug total. we resist reducing becuase we dont know if cancer is still there. she has been ned for over ayr. plats are the issue , and liver irritation from drug. plats are in 60-s to 70's . L. is now in a rollover or extension study , beyond eap. rules have been flexed for her to have option to delay tx a week ( to 1x every 4 weeks ) , if plats are below 75,000, and hopefully to also liver counts down below 100. lately they have been in 70-s to just over 100.

12-10-2012, 08:55 AM	#2
phil Senior Member Join Date: Nov 2010 Posts: 393	Re: TDM1 dosage In the expanded access there are 2 dose reductions, to 3.0 from 3.6 then to 2.4 . Lorraine is hanging in at 3.0 for well over a yr, 2 yrs on drug total. we resist reducing becuase we dont know if cancer is still there. she has been ned for over ayr. plats are the issue , and liver irritation from drug. plats are in 60-s to 70's . L. is now in a rollover or extension study , beyond eap. rules have been flexed for her to have option to delay tx a week ( to 1x every 4 weeks ) , if plats are below 75,000, and hopefully to also liver counts down below 100. lately they have been in 70-s to just over 100.