[Rolepaul]

Tell your daughter's doctor to get to 1.3 to 1.6 mg/kg of body weight now that the treatment has not shown significant side effects. When Nina went from 40 mg to 80 mg, and then up to 100 mg, we saw a real improvement in the lesions in the brain and spine. It took 60 to 90 days of once per week IT Herceptin and twice per week Topotecan to get the MRI scans clean at 80 mg of Herceptin in a 60 kg (135 pound woman). Nina has just the opposite issue with her treatment, perhaps because of the Navelbine IV. She is constipated and has significant doses of stool softeners. I can tell you that in all probability the doctor is following the protocol that was developed for Nina at MD Anderson as it has gotten rid of the brain and spine lesions. Send a private email and I can give you my aol.com account info. Have hope as this has a great chance of being effective!