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Re: Dramatic increase in survival (7x longer) when combine antiangiogenic 2 two antih
This is very interesting. I don't have brain mets, but a month ago I was on the brink of death due to lymphangetic spread and micro tumor emboli along with dehydration. My doctor didn't think I had a week, so he began me on avastin with herceptin, tykerb and abraxane. I was on oxygen 24/7 for 2 months, and I am now off of it. My breathing is improving everyday. The other doctors on my team are dumbfounded by my improvement. In my research about this type of spread, it often goes hand in hand with VEGF and angiogenisis, which is why we added avastin. I sure hope they can get this combo into trials and reinstate avastin for BC soon! I know Hope Rugo was interviewed about this and mentioned not throwing the baby out with the bath water re avastin. I think they may be looking at testing people for VEGF and then seeing if those who test pos respond to avastin.
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March 2010: Diagnosed with Stage IIIC IDC with axillary, mammary and suplaclavicular node involvement. ER/PR -, HER2+++. 7cm tumor in right breast.
April 2010: Started neoadjuvent chemo. 4 DD A/C every 2 weeks, 4 DD Taxotere every 3 weeks with Herceptin weekly.
August 2010: Finished chemo!
August 20, 2010: PET/CT showed no cancer in any nodes, and only a little uptake to the breast.
September 9, 2010: Bilateral mastectomy with immediate reconstruction with implants and Alloderm.
September 16, 2010: Pathology report showed 18/51 positive axillary nodes, 3.2cm tumor. Granual sized cancer found in the fatty tissue between levels 1 and 2.
October 19, 2010: CT showed several spots on lungs and 1 spot on liver. Liver spot is 2mm, lung spots range from 2mm to 4mm. We don't know if they are cancer or not.
12/15/10: Brain MRI clear
1/7/11: PET/CT
1/13/11: Recurrence in lungs. Start Tykerb
5/13/11: Progression in lungs
6/3/11: Lung surgery to get tumors for chemosensitivity testing.
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