I'm sorry to hear about Barb's progression with TDM-1. I've been following your updates with hope and this is disappointing for me too
I was wondering if you've explored Perjeta/Herceptin and Taxol combo. There's this thread on BCO where the ladies have had good results with this. Hopefully this will reverse the Herceptin resistance. Not sure if I'm breaking any rules by posting the thread here, but I'll just post it for your ease of reference.
http://community.breastcancer.org/forum/8/topic/790575
Of course, I've my fingers crossed that Halaven does a good job and you won't have to explore the Perjeta combo..